BioShock 2 - You play as a Big Daddy
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Yes, finally, we can tell you that you play as a Big Daddy in BioShock 2.
Subs issues of Game Informer have hit, confirming that you take control of the first gigantic walking chap thing, have changeable weapons for your arm and new, mutated plasmids.
You can now adopt Little Sisters, as well as either killing them or saving them.
There's more on Shacknews, which is a culmination of stuff from the Gamespot forums and NeoGAF. It's unconfirmed as yet, but it's true, if you know what we mean.